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and 81473393, X.D.), the Natural Science Foundation of Heilongjiang Province (LC2015030, S.L.), the China Postdoctoral Science Foundation (2015M570302 and 2016T90315 to S.L.), and the National Basic Program Research of China (973 program, 2014 CB543001, X.D.)

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[13] Infectious trigger [edit] Since Graves disease is an autoimmune disease that appears suddenly, often later in life, a viral or bacterial infection may trigger antibodies, which cross-react with the human TSH receptor, a phenomenon known as antigenic mimicry

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Topical application of steroid gargle, ointment, tacrolimus, pregabalin and low-level LASER therapy are recommended [94,95,96,97]